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Description: Whole mounts on the left. In the upper section on the right, staining with anti-Gata4 identified by the red color locates Sertoli cells within the developing testis that will converge to form progenitors of the seminiferous tubules. Positive staining is absent in the mesonephros and in germ cells. In the lower section on the right, faint staining with anti-Mis (Mullerian Inhibiting Substance, also known as AMH, anti-Mullerian Hormone) defines the onset of functionality of developing Sertoli cells. McCoard et al., (J. Endocrinology 175:365, 2002) published higher power images of Mis and Gata4 immunoreactive cells within the developing testes. SRY, encoded by a gene on the Y chromosome, initiates the cascade of changes leading to testicular differentiation and development of the male phenotype.

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